Evaluation of promoting effect of several transdermal enhancers with RSR

Objective To investigate the application of RSR in evaluating the promoting effect of transdermal enhancers. Methods Diclofenac sodium was used as drug mode. 1% borneolum,1% azone,1% menthol,1% borneolum+ 1% azone,1% menthol+ 1% azone and 1% borneolum+ 1% azone+ 1% menthol were used as transdermal enhancers. Transdermal absorption experiment of diclofenac sodium was detected on the device of penetrating skins of rat in vitro and lag time,penetrating rates,steady fluxes and enhancement ratio were calculated to evaluate the promoting effect of transdermal enhancers with RSR. Results The promoting effect on diclofenac sodium showed that 1% borneolum+ 1% azone+ 1% menthol and 1% menthol+ 1% azone were the best. The function drops slightly with 1% azone+ 1% borneolum,1% menthol and 1%azone ranked behind. The worst was 1% borneolum. Conclusion The promoting effect of transdermal enhancers could be objectively evaluated by RSR.