Study on clinical and hemorrheology of alprostadil injection in the treatment of I-II stage idiopathic membranous nephropathy

Objective: To observe clinical and blood rheology effect of alprostadil to I- II stage idiopathic membranous nephropathy. Method: 36 cases of renal biopsy for the diagnosis of I- II in patients with idiopathic membranous nephropathy were randomly divided into two groups,The control group and treatment group,each group consists of 18 cases. The two groups were both given prednisone and cyclophosphamide treatment,the treatment group was combined with alprostadil on the basis of routine treatment. Before and after treatment,24 h urinary protein,plasma albumin,serum creatinine,creatinine clearance rate and the indexes of blood rheology were observed. Result: After treatment of the control group and the treatment group,24 h urinary protein decreased significantly,and plasma albumin was significantly increased,there was statistical significance( P 0. 05),Serum creatinine,endogenous creatinine clearance rate had no obvious changes,there was no statistical significance( P 0. 05). After treatment,the 24 h urine protein quantitative,and plasma albumin of the treatment group were significantly better than the control group,there was statistical significance( P 0. 05). After treatment of patients in the control group,the whole blood viscosity,plasma viscosity,fibrinogen and blood rheology indicators were no significant difference compared with before treatment( P 0. 05),While the blood rheology of the treatment group improved significantly compared with before treatment( P 0. 05). At the same time,the blood rheology of the treatment group had significant difference compared with the control group of patients after treatment( P 0. 05). Conclusion: Alprostadil can not only reduce proteinuria in patients with stage I- II idiopathic membranous nephropathy,increase the plasma albumin level,but also improve the blood microcirculation,reduce the possibility of thrombosis,which can effectively delay the progression of renal disease.