Observation on Curative Effect of Tourette Syndrome Treated with Topiramate

Objective To discuss curative effect and dosage of topiramate to treat Tourette syndrome.Methods 40 cases of such patient were divided into therapy group(21 cases) and control group(19 cases).On the bases of psychotherapy,the control group was treated with vesalium 4.0~12 mg/d bid.And therapy group was treated with topiramate of dosage from 0.5 mg/kg/d,to 1.0 mg/kg twice a day,and increased 0.5 mg/kg every one or two week to 3.0 mg/kg/d for 3 months.The curative effect and spasm condition were observed and followed in OPD.Results The effective rate was 95.6% in therapy group and 85% in control group with significant difference between two groups.Conclusion The small dosage of topiramate might have better curative effect with less side effect.