Effects of Tongxinluo Capsule on Blood Lipid and Inflammatory Factor in Acute Cerebral Infarction Patients with Type 2 Diabetes Mellitus

Objective: To explore the clinical effect of Tongxinluo capsule on blood lipid and inflammatory factor in acute cerebral infarction patients with type2 diabetes mellitus(T2DM). Methods: The 154 cases were randomly divided into combination group, simvastatin group and Tongxinluo group. Patients in the three groups all received the ACI conventional treatments. The simvastatin group was additional given simvastatin, while the Tongxinluo group added Tongxinluo capsule. Patients in the combination group were given simvastatin and Tongxinluo capsule based on the ACI conventional treatment. After 4 weeks' treatment,the clinical effects of these groups were observed. Results: After treatment, the levels of TC, TG, HDL-C and LDL-C in the three groups all improved(P0.01). The levels of TC, TG and HDL-C of the simvastatin group and Tongxinluo group were higher than that of combination group(P0.01), while the HDL-C was lower than combination group(P0.01). The Tongxinluo group had higher TC and TG level than the simvastatin group(P 0.01). The levels of hs-CRP, TNF-α, IL-1and IL-6 of all the groups decreased obiviously than before(P 0.01). The simvastatin group and Tongxinluo group had higher IL-1, IL-6, TNF-αand hs-CRP than the combination group(P0.01), whlie the four inflammatory factors in the simvastatin group were lower than that of Tongxinluo group(P0.05). Conclusion: The Tongxinluo capsule has the advantage of improving the inflammatory response after ACI and adjusting the dyslipidemia, it shows better effects when combined with simvastatin.