Clinical observation of the effect of magnesium sulfate in the treatment and prevention of cerebral vasospasm after subarachnoid hemorrhage

Objective:To investigate the curative effect of magnesium sulfate in the treatment and prevention of cerebral vasospasm(CVS) after subarachnoid hemorrhage(SAH).Methods:54 patients with SAH were randomized into two groups,the treatment group(28 cases) and control group(26 cases).The routine therapy was used in both groups,besides this the treatment group was added with magnesium sulfate.All the patients were detected by transcranial Doppler scanning.Results:Suffered from CVS after SAH,there were 4 cases accounting for 14.3% in the treatment group and 13 cases accounting for 50% in the control group.The contracting peak velocity(Vp) of cerebral arteries after treatment with magnesium sulfate changed more significantly compared with that of the control group(P0.01),and also with that before treatment(P0.01).The difference before and after treatment was not significant in the control group(P0.05).Conclusion:The curative effect of magnesium sulfate in the treament and prevention of cerebral vasospasm after subarachnoid hemorrhage is definete.