Diagnosis Value of Chronic Atrophic Gastritis by Mesasuring Serum Pepsinogen and Gastrin

Objective To search the relationship between serum PGⅠ,PGⅠ/PGⅡ ration(PGR) and gastrin-17(G-17) and chronic atrophic gastritis and to establish the changes of serum PGⅠ,PGⅠ/PGⅡ ratio(PGR) and G-17 in patients with chronic atrophic gastrits.Methods 300 patients who underwent endoscopy were recruited according to the inclusion criteria.Based on histopathologic diagnosis criteria,these patients were divided into two groups:One was chronic non atrophic gastritis group(n=202),the other was chronic atrophic gastrits group(n=98).Fasting serum samples of PGⅠ,PGⅡ and G-17 determination were analyzed by enzyme-linked immunosorbent assay(ELISA);The ratio of PGⅠ/PGⅡ(PGR) was calculated.Infection of helicobacter pylori(Hp) was determined by 13C or 14C-urea expiration test and rapid urease test.Results In chronic atrophic gastritis group compared to those in the chronic non atrophic gastritis group,serum levels of PGⅠ(128.55±61.42 μg/L and 150.61±75.33 μg/L) was significantly decreased(P0.05);PGR vlue(10.09±5.15 and 10.95±7.18) had no significantly decreas(P0.05);G-17(9.68±15.51 pmol/L and 18.93±18.92 pmol/L) was significantly decreased(P0.05).Hp positive group compared to those in the Hp negative group,serum level of PGⅠ(125.39±65.90 μg/L and 154.19±65.13 μg/L) was significantly decreased(P0.05);serum level of PGR(8.96±7.22 and 11.63±5.66) was significantly decreas(P0.05);serum level of G-17(10.91±15.50 poml/L and 10.68±19.12 pmol/L) had no signficantly decreas(P0.05).Conclusion Detection of serum PG and G-17 levels can be used in the screening of chronic atrophic gastritis.If abnormal,endoscopy should be performed to make final diagnosis and guide the treatment.Hp infection is related to the change of PG level.