The diagnostic value of detecting peripheral lymphocytes of the hand,foot and mouth disease

Objective To investigate the value of the peripheral lymphocytes detection in the guiding children patients with hand,foot and mouth disease(HFMD).Methods 68 cases of children patients with HFMD hospitalized for observation during April to July in 2012 were tested the peripheral white cell count.The test data were randomly divided into two groups according to the reference value,including 38 cases of the leukocyte group(increased group) and 30 cases of the white blood cells(normal group).The numerical changes of peripheral lymphocytes in the two groups before and after treatment as well as the evolution and transformation of the indicators were observed,and we explored the value of the results for guiding clinical diagnosis of HFMD.The two groups of children were correspondingly treated with Xiyanping Yanhuning Tanreqing ribavirin and water-soluble vitamin symptomatic,and those whose white blood cells or CRP significantly increased were given antibiotic,mainly cefuroxime sodium for routine,treatment,in which those who were allergy to cephalosporins were given a conventional amount of clindamycin treatment.Results Compared with the normal white blood cell group,the leukocyte white blood cells after the treatment decreased significantly in the increased group compared with that before the treatment,in which the neutrophils mainly decreased.While the lymphocytes decreased slightly.After treatment,The mean of white blood cell in the normal group increased slightly after the treatment,while the average number of neutrophils decreased and mean of lymphocyte became significantly higher.Comparing the therapeutic effect of the two groups,the cure time of the increased group was shortened,and the statistical difference of the two groups was significant(P0.01);While the average body temperature recovery time of the increased group was longer than that of the normal group,and the statistical difference of the two groups was significant(P0.01).Conclusion The difference of the average number of white blood cell between the two groups after the children HFMD patients being treated with this program has statistical value,but the results are close;The increased group has increased significantly and the normal group decreased slightly.The mean number of neutrophil of the normal group decreased significantly while the mean number of lymphocyte does not change much.In the meantime,the granulocytes of the normal group decreased significantly,while lymphocytes increased significantly.The decrease of granulocytes was the main type of peripheral blood cells changes in the increased group,which does not completely comply with the common feature of viral infection.While the increase of lymphocytes is the main type of change in the normal group,and in line with the common feature of viral infection.