Application of Clopidogrel Combined with Aspirin in Treatment of Acute Mild Cerebral Infarction

Objective To investigate the curative effect and safety of Clopidogrel combined with Aspirin in treatment of acute mild cerebral infarction. Methods A total of 356 patients with acute mild cerebral infarction within 72 h invasion during September 2011 and Septembers 2012 were randomly divided into Aspirin and Clopidogrel group( group A,n = 178) and Aspirin group( group B,n = 178). The course of treatment of each group was 14 d. Progressions of pathogenetic condition,scores of national institute of health stroke scale( NIHSS) upon admission and after treatment, and incidence rate of adverse reactions in the two groups were observed. Results Aggravation rate of the group A was lower than that of the group B( P 0. 05). There were no significant differences between the two groups in NINSS scores at admission and after treatment( P 0. 05),but the score after treatment in each group was lower than that upon admission( P 0. 05). There was no severe adverse reaction. Conclusion Clopidogrel combined with Aspirin in treatment of acute mild cerebral infarction may effectively reduce aggravation rate and improve the prognosis with good safety.