The Rsearch on Effecfs of Intervention of PL、NM to rCBF、 Brain Water Content and Neurological Symptoms after ICH in Rats

The nonheparinized arterial blood was injected into the Caudate nucleus of the rat to establish a model of ICH (intracerebral hemorrhage) in this Study, to Compare the groups of ICH with the pops of ICH and intervened by PL.NM to observe the changes of rCBF, brain symptoms, to measure different time rCBF of the brain surrounding the hematoma and distnat structures by hydrogen Clearance method. Brain water content in R1, R2, R3, R4at 4, 12, and 24 hours after ICH was determined by the wet and dry weighing method, Neurological symptom evaluation was undertaken at 4, 12, 24,48 and 72 hours after experimental ICH. The results were as follows: In the areas around the hematoma and distant from hematoma of the ICH groups, which were intervened by PL, and NM, rCBF increased evidently, brain water content was reduced, neurological Symptoms were improved obviously, there were obviously difference(P 0. 05 on 0. 01 ) by comparing with the groups of ICH. Thus, PL.NM are calcium Charmal blockers could improve rCBF.brain water content and neurological symptoms after ICH in rats.