Analysis of Blood Aminophylline Concentration Monitoring in 228 Patients

OBJECTIVE:To give some information for a rational administration of aminophylline for patients and put forward individual does proposal by the analysis on blood drug concentration of aminophylline of 228 cases. METHODS:plasma aminophylline concentration monitoring materials and relevant clinical information were analyzed of 228cases. RESULTS:Plasma aminophylline concentration were range of 5～20 μg·mL-1 in patients,accounting for 20.6% of total cases observed,more than 20 μg·mL-1 in patients,accounting for 3.5%,and lower than 5 μg·mL-1 in patients,accounting for 75.9%. Clinical manifestation in digestive,circulatory,and nervous systems et al can be observed in patients with plasma aminophylline concentration were more than 20 μg·mL-1. Significant change of plasma aminophylline concentration can be observed in patients who combine aminophylline and other kinds of drug. CONCLUSION:Plasma aminophylline concentration should be monitored in clinical usage and the influencing factors,such as physical,pathology and combing usage should be noticed closely.