Relation of idiopathic thrombocytopenic purpura with Helicobacter pylori

Objective Clinical research was made to observe the relationship between idiopathic thrombocytopenic purpura(ITP)and Helicobacter pylori(Hp)and to evaluate the effect of Hp eradication in the treatment of refractory ITP.Methods 13C urea breath test and Hp antibody of serum were made in 48 previously untreated patients with ITP from Department of Hematology of the First Affiliated Hospital of China Medical University during November 2004 to May 2005 years and normal controls consisted of 52 heathy peoples whose gastroscopy was normal.Omeprazole,clarithromycin and amoxicillin were used for Hp eradication to refractory ITP with Hp infection.13C urea breath test,Hp antibody of serum and the level platelet and PAIgG was detected after therapy 4~8 weeks.Results Of 48 cases with ITP,33(68.18%)had Hp infection and 24 of 52(46.12%)normal population had Hp infection,the infection rate of Hp in ITP patients being statistically higher than the control group(P0.05);11 cases of refractory ITP with Hp infection were treated by Hp eradication.Eight of 11 cases got rid of it.The level of PAIgG of 6 cases was not detected.The average level of platelet was higher than that before therapy(P0.05).Conclusion The prevalence of Hp infection is higher in ITP patients than in general population;Hp eradication is effective in the treatment of refractory ITP.