The oberservation of concentration of serum and CSF neuron-specific enolase in patients with encephalic infections

Objective to observe the change of concentration of serum and CSF neuron-specific enolase(NSE) in patients with encephalic infections and to explore the clinical value of that.Methods RIA was rented for concentration of serum and CSF NSE in 40 patients with encephalic infections[18 viral encephalitis(VE),14 tuberculomeningitis(TM),8 purulentmeningitis(PM)]and 23 control subjects.Results The concentration of serum and CSF NSE were significantly higher in observed group than control group(P0.05);The concentration of NSE:VETMPM(P0.05);NSE in serum is positively correlated with NSE in CSF.Conclusion There is closely corration beteen the concentration of NSE and the encephalic damage;The concentration of serum NSE can be served as facility marker for evaluating the damage of encephalic infections.