Roles of CD_4~+CD_(25)~+CD_(low)~(127) regulatory T cells and related cytokine in children with aplastic anemia

Objective To explore the levels of CD+4CD+25CDlow127 regulatory T cells(Tregs) and TGF-β1 in peripheral blood of aplastic anemia(AA) in children,and to investigate the role of Tregs in the pathogenesis of aplastic anemia.Methods A total of 21 patients with chronic aplastic anemia(CAA),9 patients with acute aplastic anemia(SAA) and 15 normal healthy children were included in this study.The proportion of CD+4CD+25CDlow127 T cells in CD+4 T cells was evaluated by flow cytometric analysis.TGF-β1 was measured by ELISA.Results The percentage of CD+4 T cells,CD+4CD+25 T cells.Tregs in peripheral blood and serum TGF-β1 expression in patients with AA were lower than those in the normal control(all P0.05).The percentage mentioned above in SAA was lower than that in CAA(all P0.05).Tregs percentage and the level of TGF-β1 in children with AA were no significant correlation.Conclusions The low percentage of regulatory T cells and the low level of TGF-β1 in children may be involved in pathophysiology of AA.