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Alterations of CD4~+Treg cells in peripheral blood of aplastic anemia patients and its clinical significance

Lulu Li

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Abstract

Objective To study the frequency and clinical significance of the regulatory T cells(Treg cells) in patients with aplastic anemia(AA).Methods The percentage of CD4+CD25+/ CD4+ T cells and CD4+ FOXP3+/CD4+T cells in peripheral blood were examined with flow cytometry in 20 patients with AA by the direct immunofluorescence test.The control group was 22 healthy people.Results The proportion of CD4 +FOXP3 +/CD4 + T cells in AA group was obviously lower than that in control group(P0.01);The proportion of CD4+CD25+ /CD4+T cells in the AA group was obviously lower than that in control group(P0.01).Conclusion The decrease of CD4+Treg cells is speculated to have association with impaired immune homeostasis and development of aplastic anemia.

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Objective To study the frequency and clinical significance of the regulatory T cells(Treg cells) in patients with aplastic anemia(AA).Methods The percentage of CD4+CD25+/ CD4+ T cells and CD4+ FOXP3+/CD4+T cells in peripheral blood were examined with flow cytometry in 20 patients with AA by the direct immunofluorescence test.The control group was 22 healthy people.Results The proportion of CD4 +FOXP3 +/CD4 + T cells in AA group was obviously lower than that in control group(P0.01);The proportion of CD4+CD25+ /CD4+T cells in the AA group was obviously lower than that in control group(P0.01).Conclusion The decrease of CD4+Treg cells is speculated to have association with impaired immune homeostasis and development of aplastic anemia.

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Available abstract

Objective To study the frequency and clinical significance of the regulatory T cells(Treg cells) in patients with aplastic anemia(AA).Methods The percentage of CD4+CD25+/ CD4+ T cells and CD4+ FOXP3+/CD4+T cells in peripheral blood were examined with flow cytometry in 20 patients with AA by the direct immunofluorescence test.The control group was 22 healthy people.Results The proportion of CD4 +FOXP3 +/CD4 + T cells in AA group was obviously lower than that in control group(P0.01);The proportion of CD4+CD25+ /CD4+T cells in the AA group was obviously lower than that in control group(P0.01).Conclusion The decrease of CD4+Treg cells is speculated to have association with impaired immune homeostasis and development of aplastic anemia.

Key concepts: Aplastic anemia, FOXP3, IL-2 receptor, Flow cytometry, Immunology, Treg cell, Immune system, Medicine

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Alterations of CD4~+Treg cells in peripheral blood of aplastic anemia patients and its clinical significance — Research Paper | ScholarLens