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The relationship among c-met oncogene,CD44v6 oncogene with PCNA in HP infected patients.

Shi Min-xi

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Abstract

Objective To determine the relationship among c-met,CD44v6 oncogene with proliferating cell nuclear antigen(PCNA)in Helicobacter Pylori(HP) infected gastric mucosal lesions.Methods Expression of c-met and PCNA were studied in 114 gastric mucosal lesions by using immunohistochemistry.HP was examined by both Warthin-starry method and RUT.Results Patients HP positive compare to patients HP negative,the expression of c-met,PCNA and CD44v6 has a significant statistical difference (P0.05).Expression of c-met and CD44v6 were correlated significantly in HP infected patients(rs=0.4779,P0.01).Conclusion HP may promote the process of gastric mucosal lesions Hp infection may activate the expression of c-met,PCNA and CD44v6 in precarcinoma and cause some oncogene correlated.

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What this paper is about

Objective To determine the relationship among c-met,CD44v6 oncogene with proliferating cell nuclear antigen(PCNA)in Helicobacter Pylori(HP) infected gastric mucosal lesions.Methods Expression of c-met and PCNA were studied in 114 gastric mucosal lesions by using immunohistochemistry.HP was examined by both Warthin-starry method and RUT.Results Patients HP positive compare to patients HP negative,the expression of c-met,PCNA and CD44v6 has a significant statistical difference (P0.05).Expression of c-met and CD44v6 were correlated significantly in HP infected patients(rs=0.4779,P0.01).Conclusion HP may promote the process of gastric mucosal lesions Hp infection may activate the expression of c-met,PCNA and CD44v6 in precarcinoma and cause some oncogene correlated.

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Available abstract

Objective To determine the relationship among c-met,CD44v6 oncogene with proliferating cell nuclear antigen(PCNA)in Helicobacter Pylori(HP) infected gastric mucosal lesions.Methods Expression of c-met and PCNA were studied in 114 gastric mucosal lesions by using immunohistochemistry.HP was examined by both Warthin-starry method and RUT.Results Patients HP positive compare to patients HP negative,the expression of c-met,PCNA and CD44v6 has a significant statistical difference (P0.05).Expression of c-met and CD44v6 were correlated significantly in HP infected patients(rs=0.4779,P0.01).Conclusion HP may promote the process of gastric mucosal lesions Hp infection may activate the expression of c-met,PCNA and CD44v6 in precarcinoma and cause some oncogene correlated.

Key concepts: Proliferating cell nuclear antigen, Oncogene, Immunohistochemistry, Helicobacter pylori, Medicine, Cancer research, Cancer, Pathology

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The relationship among c-met oncogene,CD44v6 oncogene with PCNA in HP infected patients. — Research Paper | ScholarLens