Structure and Mechanism of OPG & RANK & RANKL and Their Effect on Bone Diseases

Osteoclast regulates bone resorption and osteoblast is important in bone composition, and OPG RANK RANKL play an important role in the regulation of their ratio. RANKL combined with RANK to be concerned with osteoclast differentiation, which promote bone resorption; however, RANKL combined with OPG to inhibit osteoclast developing, which inhibit bone resorption. There is some ratio between RANKL/RANK and RANKL/OPG. If the ratio loses its balance, living organism will get some bone disease. At the same time OPG RANK RANKL are immunology molecules . It was reported that bone diseases have some connections with immunology system. This review considers recent advances in knowledge about structure and mechanism of OPG RANK RANKL and their effect on bone diseases.