The predictive values of B-type natriuretic peptide for the heart function and prognosis in patients with severe sepsis and septic shock

Objective: To study the predictive values of B-type natriuretic peptide for the heart function and prognosis in patients with severe sepsis and septic shock.Methods: 68 patients of severe sepsis and septic shock were prospectively studied,68 patients into ICU were tested BNP and left ventricular ejection fraction measured arterial blood(LVEF) in 24 h,dividing the patients into the normal heart function and heart failure group according to LVEF,BNP levels were compared between two groups,19 patients died as the 28 d hospital death group,49 survived,as the survival group,retrospective analysis of two groups of BNP,BNP predicted by ROC curve analysis threshold of death.Results: ① BNP in patients with heart failure group was significantly higher than normal cardiac function in patients with BNP level group(P0.05).② BNP level of the death group was significantly higher than that of the survival group,BNP level 691.8 ng/L was critical value for the prediction of death,the sensitivity was 91.7%,specificity was 80.7%(P0.05).Conclusion: Severe sepsis and septic shock patients are significantly higher BNP levels,and BNP levels have a predictive value for the patients to prognosis of heart function.