Effects of ZhongFengGao on Level of Blood Fat and Vascular Endothelial Function of Rabbits with Atherosclerosis

Objective:To explore the mechanism of ZhongFengGao on rabbits with atherosclerosis(AS).Method: All 50 rabbits were randomized into blank control group,model group,low and high dose groups of ZhongFengGao groups as well as treatment group of simvastatin.Except blank control group,other groups were fed with high cholesterol food to build the models with AS.Contents of TC,TG and LDL-c in the serum were detected with automatic biochemical analyzer;NO content was measured with spectrophotometer and ET-1 content with radioimmunoassay;tissue slice of carotid artery was stained with HE and observed under light microscope.Result: Contents of TC,TG and LDL-C in the serum of AS group were higher than that of the control group(P0.05).Pathomorphology suggested that there were typical atheromatous plaque appeared on paries carotica of AS group,there was no abnormality in the control group,which meant that the models were successfully copied.Contents of TC,TG and LDL-C in the serum decreased but NO rose in low and high dose groups of ZhongFengGao groups and treatment group of simvastatin,compared with the control group,it showed significant difference(P0.05).Shape and areas of plaque in rabbits with AS of high dose group of ZhongFengGao and treatment group of simvastatin were improved greater than that of the control group and low dose group of ZhongFengGao(P0.05).Conclusion: ZhongFengGao could obviously lower the levels of TC,TG,HDL-c and ET-1,raise NO level to protect vascular endothelial cell and against AS.