Clinical curative effect of mixture formulas based on disease and syndrome in treatment of damp-heat blockage syndrome of rheumatoid arthritis

Objective To observe the effectiveness and safety of the therapeutic plan based on syndrome differentiation and treatment and pharmacological research in the treatment of damp-heat blockage syndrome of rheumatoid arthritis.Methods The patients with damp-heat blockage syndrome of rheumatoid arthritis(n=64) were chosen and randomly divided into the treatment group and control group(each n=32).The control group was given loxoprofen sodium tablets and methotrexate tablets orally and the treatment group was given Chinese medicinal based on disease and syndrome treatment besides Western medicine treatment.The therapeutic course was 12 weeks.The criteria of the American College of Rheumatology(ACR) was taken as the criteria of total curative effect education.Results After 12 weeks,the improvement of all indexes in the patients of two groups had statistical difference(all P0.01) compared with those in the same group before treatment.The results of pain scores(VAS scores),morning stiffness time,numbers and index of arthroncus,numbers and index of joint tenderness,grip strength,disease activity scores of 28 joints(DSA28 scores),health appraisal questionnaire(HAQ),patient's evaluation and ESR were all much better in the treatment group than those in the control group with significant difference(all P0.05).In the treatment group ACR20,ACR50 and ACR70 was,respectively,23.34%(7/30),40.00%(12/30) and 23.34%(7/30) and in the control group,40.63%(13/32),28.13%(9/32) and 9.38%(3/32).The difference between two groups had statistical significance(P0.05).The occurrence rate of adverse reactions was higher in the control group than that in the treatment group(P0.05).Conclusion The therapy based on disease and syndrome treatment has obvious curative effect and can reduce the adverse reactions induced by Western medicinal in the treatment of damp-heat blockage syndrome of rheumatoid arthritis.