Study on combination treatment with leukapheresis and plateletpheresis in patients with chronic myeloid leukemia

Objective To evaluate the practicability and methods of combination treatment with leukapheresis and plateletpheresis sequencially in chronic myeloid leukemia (CML) patients with leukocytosis and thrombocytosis. Methods Ten CML patients with leukocytosis and thrombocytosis were treated sequentially with a single Apheresis Kit by using CS 3000 plus blood cell separator. Leukapheresis or plateletpheresis was performed at first. Then empty the Collection Container, switch to another procedure and Container Holders. Clinical index including WBC, PLT, symptoms and signs were recorded before and after treatment. Results After treatment, WBC count decreased by (55.2±21.2)% and PLT count by (47.8±10.2)%, symptoms and signs improved or disapeared. Conclusion Combination treatment with leukapheresis and plateletpheresis sequentially with a single Apheresis Kit is a safe, effective, practicable and economic method in the treatment of CML patients with leukocytosis and thrombocytosis.