The application of platinum drugs in the treatment of cancer

The important progress in platinum drugs has been witnessed in past nearly half a century. On the one hand,new platinum drugs such as nedaplatin, oxaliplatin, lobaplatin and sunpla have continuously emerged, and put into use in clinic after clinical trials were successfully completed. The analogues of cisplatin and carboplatin, the lipophilic and sterically hindered complexes and even some oral platinum complexes are in clinical trials, some of which will become new-type platinum drugs in the near future. On the other hand, combination of platinum with other anticancer drugs has significantly improved the anticancer efficacy and some important breakthroughs have been made in platinum-induced chemoresistance research.