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Establishment of experimental animal model of chicken liver and kidney damages induced by carbon tetrachloride

NI Jia-ning

Open publisher page 3 citations

Abstract

The purpose of this study is to establish experimental animal models about the injury of liver and kidney which are convenient for clinical practice,scientific research and teaching.We examined the changes of alanine aminotransferase(ALT),aspartate aminotransferase(AST)in serum and histopathological injury of liver and kidney after drenching carbon tetrachloride(CCl4)to chicken.The liver damage caused by CCl4 showed a cumulative toxic effection.The inductions of the serum transaminases were dependent on CCl4 dosage.The activity of ALT in the chicken serum revealed the induction tendancy with CCl4 dosage.The histopathological lesions in the liver were characterized by typical vacuolar degeneration.

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What this paper is about

The purpose of this study is to establish experimental animal models about the injury of liver and kidney which are convenient for clinical practice,scientific research and teaching.We examined the changes of alanine aminotransferase(ALT),aspartate aminotransferase(AST)in serum and histopathological injury of liver and kidney after drenching carbon tetrachloride(CCl4)to chicken.The liver damage caused by CCl4 showed a cumulative toxic effection.The inductions of the serum transaminases were dependent on CCl4 dosage.The activity of ALT in the chicken serum revealed the induction tendancy with CCl4 dosage.The histopathological lesions in the liver were characterized by typical vacuolar degeneration.

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Available abstract

The purpose of this study is to establish experimental animal models about the injury of liver and kidney which are convenient for clinical practice,scientific research and teaching.We examined the changes of alanine aminotransferase(ALT),aspartate aminotransferase(AST)in serum and histopathological injury of liver and kidney after drenching carbon tetrachloride(CCl4)to chicken.The liver damage caused by CCl4 showed a cumulative toxic effection.The inductions of the serum transaminases were dependent on CCl4 dosage.The activity of ALT in the chicken serum revealed the induction tendancy with CCl4 dosage.The histopathological lesions in the liver were characterized by typical vacuolar degeneration.

Key concepts: Carbon tetrachloride, CCL4, Alanine aminotransferase, Kidney, Liver injury, Animal model, CARBON TETRACHLORIDE POISONING, Liver damage

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