2004•Radiologic PracticeRequires access
Relative cerebral blood flow in evaluating the histopathologic grade of cerebral gliomas
Wu Hong
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Abstract
Objective:To assess the value of rCBF in assessing the histophathologic grade of cerebral gliomas. Methods: 18 patients with proven cerebral gliomas were studied preoperatively, using a first pass Gd DTPA T 2 weighted echoplanar perfusion sequence. The perfusion data were deconvoluted, with an arterial input function(AIF),to obtain a color map of rCBV and rCBF. The student t test was used to determine if there was a statistical difference between the mean values of rCBV or rCBF in high grade gliomas and in low grade gliomas. Results: The mean of the rCBV was 6.19 in the high grade gliomas and 1.76 in the low grade gliomas. The mean of the rCBF was 6.58 in the high grade gliomas and 1.62 in the low grade gliomas.A significant difference in each rCBV and rCBF was found between the high and low grade gliomas ( t test, P 0.01).Additionally, there was a strong correlation between the rCBV and rCBF ( r =0.911; P 0.01). Conclusion:A rCBF, besides a rCBV, can be a useful tool in the evaluation of the histopathologic grade of cerebral gliomas.