Clinical research of the three dimensional conformal radiation therapy (3D-CRT)combined with concurrent chemotherapy for esophageal cancer

Objective:To evaluate the therapeutic effetive,toxicity and survial rate of three dimensional-conformal radiotherapy(3D-CRT) combimed with chemotherapy for esophageal cancer. Methods: Total of 128 patients with esophageal cancer either inoperable or who refused operation were randomly divided into two groups:63 cases in the treatment group received 3D-CRT combined with chemotherapy DF(DDP and 5-FU),65 cases in the control group received 3DCRT alone.Radiotherapy was given with conventional fraction,the total tumor does were 50-60Gy. Results: The overall response(CR+PR) rates for the treatment group and the control group were 90.47 %,89.23%(P0.05),respectively.The one-year survival rates for the two groups were 63.49%,56.92%.(P0.05),respectively,the three-year survival rates for those two groups were 28.57 %,12.31 %( P0.05),the five-year survival rates for two groups were 16.67 %,1.53 %( P0.05) respectively.The adverse reaction manifested mainly the radiation esophagitis and radiation injury of lung,and the hematotoxicity,but they were accepted. Conclusion: Three dimensional-conformal radiotherapy combined with chemotherapy DF(DDP +5-Fu) for esophageal cancer could significantly improve the local control rate and recent effect and had slight side effect.