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Expression and significance of survivin in gastric carcinoma

Yao Zhong-xiang

Abstract

Objective:To study the expression of survivin,an inhibitor of apoptosis protein,in gastric carcinomas and its relation-ship with clinical pathology.Methods:Using immunohistochemical staining method,we examined the expression of survivin in 10 cases of chronic gastritis and 28 cases of gastric carcinomas.Results:Survivin expressed in 20 of 28(71.4%) cases of gastric carcinoma tissues and 1 of 10(10%) cases of chronic gastritis.Over expression of survivin had no relation with age,tumor depth,tumor size,and disease stage,but was significantly related to histological type.Conclusion:These data indicate that survivin plays an important role in the onset of gastric cacinoma.

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Key concepts: Survivin, Medicine, Immunohistochemistry, Gastric carcinoma, Inhibitor of apoptosis, Chronic gastritis, Pathology, Atrophic gastritis