Application of Chronotherapy in Treatment of Non-Dipper Hypertension

Objective: To observe the influence of different delivered medication time on the diurnal blood pressure rhythm of patients with non-dipper hypertension.Methods: Sixty patients with mild and moderate essential hypertension,who had 24-hour ambulatory blood pressure monitoring,were randomly divided into two groups of taking medicine in early morning and in the evening.The patients of the two groups were treated with tablet of 80～160 mg Vilsartan once a day.The treatment continued for ten weeks to observe the parameters of 24-hour ambulatory blood pressure before and after treatment and compare the changes of diurnal blood pressure rhythm of the two groups.Results: The average systolic blood pressure and diastolic blood pressure at night and the day were obviously decreased after 24 h treatment for the two groups(P0.05).The effectiveness rate of the diurnal rhythm changes of the SBP in two groups was 63.33% and 86.67% respectively.The effectiveness rate of the change of the diurnal rhythm of the DBP in two groups was 60.00% and 83.33% respectively.Conclusion: Taking medicine at night could not only steadily reduce blood pressure during 24-hour but also could effectively change the diurnal rhythm of blood pressure of patients with non-dipper hypertension so as to achieve the purpose of protecting target organs.