Effects of Compound Hypotensive Tablets Administered at Different Time Points on Pressure Rhythm and 24-hour Ambulatory Blood Pressure in Patients with Non-dipper Essential Hypertension

Objective To investigate the effects of Compound Hypotensive tablets on blood pressure rhythm and 24-hour ambulatory blood pressure in treatment of non-dipper essential hypertension.Methods In this multicenter,open-labeled,single armed,and non-controlled study,a total of 461 eligible patients with non-dipper essential hypertension entered the final analysis.Patients were randomized to taking the Compound Hypotensive tablets in the early morning or in the evening(1 tablet per day) for 6 months.The 24-hour ambulatory blood pressure before and after treatment were measured.Results Compared with the baseline level,the SBP and DBP blood pressure was dramatically reduced after treatment in both two groups(P0.05).After treatment,the blood control rate was 91.8%(202/220) in the early morning group and 91.5%(206/225)in the evening group.Compared with pre-treatment,the 24-hour systolic/diastolic blood pressure,day systolic/ diastolic blood pressure,and night systolic/ diastolic blood pressure significantly decreased(P0.05).After treatment,the pressure rhythm was changed from non-dipper to dipper in 190 patients(104 patients from the early morning group and 86 patients from the evening group).Conclusion Compound Hypotensive tablets can effectively lower the clinic blood pressure,ambulatory blood pressure,and night blood pressure in patients with non-dipper essential hypertension,wheter taking in the early morning or evening.In addition,it can adjust the abnormal rhythm of blood pressure.