Efficacy of prednisone,captopril acid combination therapy in children with nephrotic syndrome

Objective To investigate the efficacy and clinical significance on combination therapy of prednisone,captopril in children with nephrotic syndrome. Methods 62 patients suffering from nephrotic syndrome in children that meet the standard were selected and were randomly divided into the control group and the treatment group. The control group was treated with prednisone for conventional treatment,and the treatment group was treated with captopril for 8-12 course of treatment (a course was 15 days) on the basis of the control group. Content changes of urinary protein,serum albumin,serum cholesterol and triglycerides in a day were detective before and after treatment,and the therapeutic efficacy of the two groups was observed. Results Complete remission of the treatment group(64.5%) and total efficiency (89.3%) was significantly better than the control group. Complete remission of the control group was 45.2% and total efficiency was 74.2%. Urinary protein clearance time,infection control,serum albumin and triglyceride levels of the treatment group was significantly lower than the control group,and content of serum cholesterol was significantly higher than that in the control group,which showed a statistically significant difference (P 0.05). Conclusion Prednisone,captopril combined treatment of children with nephrotic syndrome has proven efficacy.