ScholarLens Back to search
2003•Journal of Qilu OncologyRequires access

Study of Effects of SKI-2053R Inhibiting Proliferation of Gastric Carcinoma Cell Line

Zuo Wen-shu

Open publisher page 0 citations

Abstract

Objective To study the effect of SKI-2053R on SGC-7901 cell line.Methods MTT assay was used to test the effects of SKI-2053R on SGC-7901 cells proliferation.Flow cytometry was employed to measure changes of the cell cycle and the expression of PCNA after the treatment of the drug.Results SKI-2053R inhibited proliferation of SGC-7901 cell line,changed the distribution of the cell cycle and decreased the expression of PCNA of the cancer cell.Conclusions SKI-2053R can significantly inhibit the proliferation of SGC-7901 cell line and the action mechanism may be correlate with the low expression of PCNA of the cancer cell.

About this research paper

What this paper is about

Objective To study the effect of SKI-2053R on SGC-7901 cell line.Methods MTT assay was used to test the effects of SKI-2053R on SGC-7901 cells proliferation.Flow cytometry was employed to measure changes of the cell cycle and the expression of PCNA after the treatment of the drug.Results SKI-2053R inhibited proliferation of SGC-7901 cell line,changed the distribution of the cell cycle and decreased the expression of PCNA of the cancer cell.Conclusions SKI-2053R can significantly inhibit the proliferation of SGC-7901 cell line and the action mechanism may be correlate with the low expression of PCNA of the cancer cell.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the effect of SKI-2053R on SGC-7901 cell line.Methods MTT assay was used to test the effects of SKI-2053R on SGC-7901 cells proliferation.Flow cytometry was employed to measure changes of the cell cycle and the expression of PCNA after the treatment of the drug.Results SKI-2053R inhibited proliferation of SGC-7901 cell line,changed the distribution of the cell cycle and decreased the expression of PCNA of the cancer cell.Conclusions SKI-2053R can significantly inhibit the proliferation of SGC-7901 cell line and the action mechanism may be correlate with the low expression of PCNA of the cancer cell.

Key concepts: Proliferating cell nuclear antigen, Cell cycle, Cell growth, Flow cytometry, Cell culture, Cell, Apoptosis, MTT assay

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Study of Effects of SKI-2053R Inhibiting Proliferation of Gastric Carcinoma Cell Line — Research Paper | ScholarLens