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2003•Chinese Journal of HypertensionRequires access

Effect of NF-kappa B in Atherosclerosis

Jing Deng

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Abstract

Objective To investigate the significance of NF kappa B's expression in endothelial cell atherosclerotic peripheral artery. Methods Endothelial cells in arterial vascular vessels(one group deriving from the atherosclerosis patients; the other group deriving from the normal persons) are detected NF kappa BP65 protein, ICAM 1 and VCAM 1 expressions by immunohistochemistry staining. Results (1)The expression of NF kappa BP65 protein, ICAM 1 and VCAM 1 in endothelial cells is much more prominent than that in the normal persons ( P 0 001). (2)NF kappa BP65 protein and ICAM 1 expressions are related in linear regression (b=0 802, P 0 001), as well NF kappa B protein and VCAM 1 expressions (b=0 711, P 0 001). Conclusion The NF kappa B activation enhanced the ICAM 1 and VCAM 1 expressions, which accelerate the development of atherosclerosis in arterial vascular vessels.

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Objective To investigate the significance of NF kappa B's expression in endothelial cell atherosclerotic peripheral artery. Methods Endothelial cells in arterial vascular vessels(one group deriving from the atherosclerosis patients; the other group deriving from the normal persons) are detected NF kappa BP65 protein, ICAM 1 and VCAM 1 expressions by immunohistochemistry staining. Results (1)The expression of NF kappa BP65 protein, ICAM 1 and VCAM 1 in endothelial cells is much more prominent than that in the normal persons ( P 0 001). (2)NF kappa BP65 protein and ICAM 1 expressions are related in linear regression (b=0 802, P 0 001), as well NF kappa B protein and VCAM 1 expressions (b=0 711, P 0 001). Conclusion The NF kappa B activation enhanced the ICAM 1 and VCAM 1 expressions, which accelerate the development of atherosclerosis in arterial vascular vessels.

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Available abstract

Objective To investigate the significance of NF kappa B's expression in endothelial cell atherosclerotic peripheral artery. Methods Endothelial cells in arterial vascular vessels(one group deriving from the atherosclerosis patients; the other group deriving from the normal persons) are detected NF kappa BP65 protein, ICAM 1 and VCAM 1 expressions by immunohistochemistry staining. Results (1)The expression of NF kappa BP65 protein, ICAM 1 and VCAM 1 in endothelial cells is much more prominent than that in the normal persons ( P 0 001). (2)NF kappa BP65 protein and ICAM 1 expressions are related in linear regression (b=0 802, P 0 001), as well NF kappa B protein and VCAM 1 expressions (b=0 711, P 0 001). Conclusion The NF kappa B activation enhanced the ICAM 1 and VCAM 1 expressions, which accelerate the development of atherosclerosis in arterial vascular vessels.

Key concepts: Kappa, Immunohistochemistry, VCAM-1, ICAM-1, Medicine, NFKB1, NF-κB, Pathology

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