Aberration antigen expression of acute lymphoblastic leukemia in children

Objective To study the aberration antigen expression of childhood acute lymphoblastic leukemia(ALL)and its clinical implication.Methods Bone marrow specimens of 54 ALL patients were evaluated to prove the diagnosis and classification by morphologic,cytochemical,immunologic and cytogenetic examinations.Results The incidence of myeloid antigen expression in 54 childhood ALL was 29.63 %.Among them,CD 13 was 25.93 %,CD 33 was 20.37 % and CD 14 was 11.11 %,no difference was found in expression of myeloid antigen between B-ALL and T-ALL(30.77 % vs 29.2 % P=0.918).Myeloid antigen were expressed munch higher in CD 34 positive ALL than CD 34 negative ALL(40.63 % vs 13.6 % P=0.039).Though complete remission rate was no difference between myeloid antigen positive ALL and myeloid antigen negative ALL(81.25 % vs 94.74 % P= 0.148),ALL children with myeloid antigen expression had shorter survival than those without myeloid antigen expression(P=0.031).Conclusions Aberration antigen expression in childhood ALL is about 29.63 %.Aberration antigen is much higher in CD 34 positive ALL than CD 34 negative ALL.ALL children with aberration antigen have shorter survival than those without aberration antigen.Aberration antigen may influence prognostic of childhood ALL.