Clinical observation of rituximab in combination with CHOP chemotherapy for B cell non-Hodgkin lymphoma

Objective:To evaluate the efficacy and toxicity of rituximab plus CHOP regimen in patients with B cell non-Hodgkin's lymphoma.Methods:9 patients received 4～6 cycles of rituximab～CHOP combination therapy.There are twenty-one days in each cycle,of each cycle,a dose of rituximab(375mg/m2)was infused in the frjst day 1,CHOP regimen were administered in the third day.Results:There were 9 patients in the study.The complete remission was observed in 7 patients,and partial remission was observed in 2 patients.The total response rate was 100%.The therapy could be well to lerated Grade ⅠⅡ myelosup pression were observed in all the patients.Conclusions:Rituximab combined with chemotherapy is a highly effective and well-tolerated treatment in B cell non-Hodgkin's lymphoma.