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HPLC determination of related substances of salicylic acid

Shan Min

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Abstract

Objective:To establish an HPLC method for determination of relater substances of salicylic acid.Methods:Phenomenex Luna C18(4.6 mm×150 mm,5 μm)was adopted with methanol-water-acetic acid(60∶40∶1) as mobile phase at the flow rate of 1.0 mL·min-1,detection was set at 270 nm.Results:Good separation of salicylic acid and other substance could be achieved.Three kinds of material and linear relationship was good,The detection limits were 0.025 μg·mL-1,0.025 μg·mL-1 and 0.04 μg·mL-1.Conclusion: This method is simple,sensitive,selective and repetitive,accurate for analysis of related substances of salicylic acid.

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What this paper is about

Objective:To establish an HPLC method for determination of relater substances of salicylic acid.Methods:Phenomenex Luna C18(4.6 mm×150 mm,5 μm)was adopted with methanol-water-acetic acid(60∶40∶1) as mobile phase at the flow rate of 1.0 mL·min-1,detection was set at 270 nm.Results:Good separation of salicylic acid and other substance could be achieved.Three kinds of material and linear relationship was good,The detection limits were 0.025 μg·mL-1,0.025 μg·mL-1 and 0.04 μg·mL-1.Conclusion: This method is simple,sensitive,selective and repetitive,accurate for analysis of related substances of salicylic acid.

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Available abstract

Objective:To establish an HPLC method for determination of relater substances of salicylic acid.Methods:Phenomenex Luna C18(4.6 mm×150 mm,5 μm)was adopted with methanol-water-acetic acid(60∶40∶1) as mobile phase at the flow rate of 1.0 mL·min-1,detection was set at 270 nm.Results:Good separation of salicylic acid and other substance could be achieved.Three kinds of material and linear relationship was good,The detection limits were 0.025 μg·mL-1,0.025 μg·mL-1 and 0.04 μg·mL-1.Conclusion: This method is simple,sensitive,selective and repetitive,accurate for analysis of related substances of salicylic acid.

Key concepts: Chemistry, Salicylic acid, Chromatography, Acetic acid, High-performance liquid chromatography, Methanol, Detection limit, Linear relationship

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