Clinical and pathological characteristics analysis for hormone receptor negative breast cancer molecular subtype

Objective To analyze the clinical features of different hormone receptor negative breast cancer subtypes HER-2 positive and triple-negative subtype),to investigate the prognostic factors of hormone receptor negative breast cancer,and try to find the evidence of combined and individualized treatment for patients with hormone receptor negative breast cancer.Methods Clinical data of 81 patients with hormone receptor negative breast cancer,treated in Wuxi maternity and child health hospital affiliated Nanjing medical university from January 2005 to July 2011,were collected and analyzed in this study.According to the HER-2 status detected by immunohistochemistry,the patients were divided into two groups: the group of triple negative,the group of HER-2 positive(IHC 3+).The difference of the clinicopathological features and prognosis among the two groups were compared.Results 51 cases were triple-negative breast cancers,30 cases were HER-2 positive breast cancers,the average age of patients with the two subtype was 49.7 and 52.7 respectively.Compared with the group of HER-2 positive,the group of triple negative and decreased significantly in the ratio of lymph node metastasis and clinical stage Ⅲ(P 0.05).There was no significant difference in size of cancer,vascular invasion,the positive rate of VEGF and P53,high level of histolog(P 0.05).The follow-up duration ranged from 7 months to 83 months,12 cases of them were found to have local tumor recurrence or distant metastatic disease.The univariate analysis showed that lymph node metastasis and vascular invasion were correlated with the disease-free survival of hormone receptor negative breast cancer.However,only vascular invasion was showed to be an independent prognostic factor assessed by multivariate analysis.Conclusion Patients with different subtype of hormone receptor negative breast cancer have different the clinicopathological features.The vascular invasion is an independent prognostic factor of the patients with hormone receptor negative breast cancer.