2003•Heilongjiang yiyao kexueRequires access
Effects of Kwoninone on hepatic stellate cell proliferation and procollagen I synthesis
Lin Minghua, Ma Yingjun, Qingyuan Meng, Yuzhen Jin, FU Chun-fang
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Abstract
objective:To study the effects of Kwoninone on hepatic stellate cell proliferation and procollagen Ⅰsynthesis to make clear its mechanism of action on liver fibrosis.Methods:The proliferation and synthesis of procollagen Ⅰwas measured by MTT bioassay,and immunocytochemistry.Result: Kwoninone significantly inhibited hepatic stellate cell proliferation and procollagenⅠ synthesis.Conclusion:The Kwoninone has anti-hepatic fibrosis effect through inhibiting hepatic stellate cell proliferation and procollagenⅠ synthesis.