Change characteristics of ambulatory blood pressure and blood pressure rhythm after blood pressure reaching standard in patients with mild or moderate hypertension

Objective To explore the change characteristics of ambulatory blood pressure and blood pressure rhythm after blood pressure reaching standard in patients with mild or moderate hypertension.Methods The patients with mild or moderate hypertension(n=124) were selected and orally given the compound preparation of irbesartan\|hydrochlorothiazide(150 mg irbesartan and 12.5 mg hydrochlorothiazide in one table) for controling blood pressure.The target blood pressure was lower than 130/85 mm Hg(1 mm Hg=0.133 kPa).The dose of medicinal was increased according to the targeting state of blood pressure.The observation was kept on for 14\|16 days.The parameters of ambulatory blood pressure and required time for blood pressure reaching standard were recorded in the patients after blood pressure reaching standard.Results There were 70 patients reaching standard blood pressure.The differences in 24\|hour systolic blood pressure(SBP),24\|hour diastolic blood pressure(DBP),diurnal average SBP and DBP,nocturnal average SBP and DBP,and pulse pressure were statistically significant(all P0.05) before and after treatment.The constituent radio of blood pressure rhythm had changes in the patients reaching standard blood pressure after the treatment,and the proportion of patients with normal blood pressure rhythm increased from 52.8% to 81.4% and the difference was statistically significant(P0.05).The required days for blood pressure reaching standard in the patients with normal blood pressure rhythm were(7.70±2.20) days and in those with abnormal blood pressure rhythm were(9.21±2.63) days(P0.05).Conclusion At the same time of improving 24\|hour blood pressure rhythm in the patients reached standard blood pressure,the administration of compound preparation of irbesartan\|hydrochlorothiazide can decrease blood pressure in the patients with mild or moderate hypertension.