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A Study on the Mechanism of Growth Inhibition by PPARgamma Ligand Rosiglitazone in the Human Gastric Carcinoma Cell Line MGC803

L Zhang

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Abstract

Objective To study the mechanism of PPARγ agonist rosiglitazone which inhibited proliferation of the human gastric carcinoma cell line MGC803.Methods MTT assay and flow cytometry were respectively used to determine the influence of rosiglitazone which effected the gasric cacinoma cell line MGC803 in its proliferation and cell cycle for 48 hours.Results The inhibitive rates of gastric carcinoma cell line MGC803 were 10.85%,32.52%,57.47%,78.94% with different concertration of rosiglitazone which was 12.5 μmol/L、25 μmol/L、 50 μmol/L、100 μmol/L respectively.The clone formation of MGC803 cell was evidently inhibited and cell cycle was arrested in G_1-phase after it was treated with rosiglitazone.Conclusion The effect of rosiglitazone which inhibited the proliferation of the human gastric carcinoma cell line MGC803 was related withG_1-phase arresting of cell cycle.

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Objective To study the mechanism of PPARγ agonist rosiglitazone which inhibited proliferation of the human gastric carcinoma cell line MGC803.Methods MTT assay and flow cytometry were respectively used to determine the influence of rosiglitazone which effected the gasric cacinoma cell line MGC803 in its proliferation and cell cycle for 48 hours.Results The inhibitive rates of gastric carcinoma cell line MGC803 were 10.85%,32.52%,57.47%,78.94% with different concertration of rosiglitazone which was 12.5 μmol/L、25 μmol/L、 50 μmol/L、100 μmol/L respectively.The clone formation of MGC803 cell was evidently inhibited and cell cycle was arrested in G_1-phase after it was treated with rosiglitazone.Conclusion The effect of rosiglitazone which inhibited the proliferation of the human gastric carcinoma cell line MGC803 was related withG_1-phase arresting of cell cycle.

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Available abstract

Objective To study the mechanism of PPARγ agonist rosiglitazone which inhibited proliferation of the human gastric carcinoma cell line MGC803.Methods MTT assay and flow cytometry were respectively used to determine the influence of rosiglitazone which effected the gasric cacinoma cell line MGC803 in its proliferation and cell cycle for 48 hours.Results The inhibitive rates of gastric carcinoma cell line MGC803 were 10.85%,32.52%,57.47%,78.94% with different concertration of rosiglitazone which was 12.5 μmol/L、25 μmol/L、 50 μmol/L、100 μmol/L respectively.The clone formation of MGC803 cell was evidently inhibited and cell cycle was arrested in G_1-phase after it was treated with rosiglitazone.Conclusion The effect of rosiglitazone which inhibited the proliferation of the human gastric carcinoma cell line MGC803 was related withG_1-phase arresting of cell cycle.

Key concepts: Rosiglitazone, Cell cycle, Flow cytometry, Cell growth, Cell culture, clone (Java method), Cell, Chemistry

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A Study on the Mechanism of Growth Inhibition by PPARgamma Ligand Rosiglitazone in the Human Gastric Carcinoma Cell Line MGC803 — Research Paper | ScholarLens