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2005•Chinese Journal of Clinical Oncology and RehabilitationRequires access

Clinical efficacy of LFPH in treatment of advanced gastric cancer

Liang Bing

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Abstract

Objective To investigate the antitumor efficacy of LFPH which is composed of HCPT,5-Fu,LV and DDP and its side effects.Methods 64 cases were divided into study group and control group.All patients received LV 100～200 mg/d by intravenous infusion (IV) in 2 hours for 5 days,5-Fu 425 mg/(m~2·d),iv,in 3 h for 5 consecutive days and DDP 30 mg/m~2,iv,for 3 days.Patients in study group also received HCPT 6-8 mg/(m~2·d),iv,for 5 consecutive days,while patients in control group received ADM 40 mg/m~2,iv in 1-2 days.Result The response rates of the two groups were 29.0% and 33.3% and there was no significant difference between the two groups.The incidences of bone marrow inhibition, alopecia, nausea and vomiting in study group were significantly lower than in control group and quality of life in study group was significantly better than that in control group. Conclusion LFPH is an effective and tolerable regimen for gastric cancer.

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What this paper is about

Objective To investigate the antitumor efficacy of LFPH which is composed of HCPT,5-Fu,LV and DDP and its side effects.Methods 64 cases were divided into study group and control group.All patients received LV 100～200 mg/d by intravenous infusion (IV) in 2 hours for 5 days,5-Fu 425 mg/(m~2·d),iv,in 3 h for 5 consecutive days and DDP 30 mg/m~2,iv,for 3 days.Patients in study group also received HCPT 6-8 mg/(m~2·d),iv,for 5 consecutive days,while patients in control group received ADM 40 mg/m~2,iv in 1-2 days.Result The response rates of the two groups were 29.0% and 33.3% and there was no significant difference between the two groups.The incidences of bone marrow inhibition, alopecia, nausea and vomiting in study group were significantly lower than in control group and quality of life in study group was significantly better than that in control group. Conclusion LFPH is an effective and tolerable regimen for gastric cancer.

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Available abstract

Objective To investigate the antitumor efficacy of LFPH which is composed of HCPT,5-Fu,LV and DDP and its side effects.Methods 64 cases were divided into study group and control group.All patients received LV 100～200 mg/d by intravenous infusion (IV) in 2 hours for 5 days,5-Fu 425 mg/(m~2·d),iv,in 3 h for 5 consecutive days and DDP 30 mg/m~2,iv,for 3 days.Patients in study group also received HCPT 6-8 mg/(m~2·d),iv,for 5 consecutive days,while patients in control group received ADM 40 mg/m~2,iv in 1-2 days.Result The response rates of the two groups were 29.0% and 33.3% and there was no significant difference between the two groups.The incidences of bone marrow inhibition, alopecia, nausea and vomiting in study group were significantly lower than in control group and quality of life in study group was significantly better than that in control group. Conclusion LFPH is an effective and tolerable regimen for gastric cancer.

Key concepts: Medicine, Nausea, Vomiting, Regimen, Bone marrow suppression, Clinical efficacy, Gastroenterology, Cancer

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