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2003•Chinese Journal of MisdiagnosticsRequires access

Clinical Significance of nm23-H1 Gene Expression in Colorectal Carcinoma

Li Wei

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Abstract

Objective To investigate the relationship between the expression of nm23-H1 gene and biological behavior of colorectal carcinoma and its prognosis.Methods nm23-H1 gene protein was detected in 121 colorectal carcinoma tissues with immunohistochemical ABC method.Results The positive rate of nm23-H1 in poor differentiated colorectal carcinomas was significantly lower than that in high differentiated one(P0.05),and the positive rate in group with lymph node metastasis was much lower than that in group without lymph node metastasis (P0.05).In clinical stage,the positive rate of Dukes A stage group was obviously higher than that of Dukes C and D stage group,respectively(P0.05).Conclusion Colorectal carcinoma with the loss of nm23-H1 gene expression had a stronger ability to infiltration and lymph node metastasis,and nm23-H1 gene could be used as an important marker for the assessment of prognosis of colorectal carcinoma.

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Objective To investigate the relationship between the expression of nm23-H1 gene and biological behavior of colorectal carcinoma and its prognosis.Methods nm23-H1 gene protein was detected in 121 colorectal carcinoma tissues with immunohistochemical ABC method.Results The positive rate of nm23-H1 in poor differentiated colorectal carcinomas was significantly lower than that in high differentiated one(P0.05),and the positive rate in group with lymph node metastasis was much lower than that in group without lymph node metastasis (P0.05).In clinical stage,the positive rate of Dukes A stage group was obviously higher than that of Dukes C and D stage group,respectively(P0.05).Conclusion Colorectal carcinoma with the loss of nm23-H1 gene expression had a stronger ability to infiltration and lymph node metastasis,and nm23-H1 gene could be used as an important marker for the assessment of prognosis of colorectal carcinoma.

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Available abstract

Objective To investigate the relationship between the expression of nm23-H1 gene and biological behavior of colorectal carcinoma and its prognosis.Methods nm23-H1 gene protein was detected in 121 colorectal carcinoma tissues with immunohistochemical ABC method.Results The positive rate of nm23-H1 in poor differentiated colorectal carcinomas was significantly lower than that in high differentiated one(P0.05),and the positive rate in group with lymph node metastasis was much lower than that in group without lymph node metastasis (P0.05).In clinical stage,the positive rate of Dukes A stage group was obviously higher than that of Dukes C and D stage group,respectively(P0.05).Conclusion Colorectal carcinoma with the loss of nm23-H1 gene expression had a stronger ability to infiltration and lymph node metastasis,and nm23-H1 gene could be used as an important marker for the assessment of prognosis of colorectal carcinoma.

Key concepts: Medicine, Colorectal cancer, Immunohistochemistry, Stage (stratigraphy), Lymph node metastasis, Lymph node, Oncology, Metastasis

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