Study on the Value of PCT in Severe Neonatal Infections

Objective: To study the value of PCT in the diagnosis of severe neonatal infections and evaluate its treatment results. Methods: Two hundred and three cases were randomly divided into four groups including general infection 58 cases, local infection 45 cases, virus infection 50 cases and non-infection control 50 cases according to history, clinical manifestations and laboratory examinations. Serum PCT, CRP, WBC count and classify, and other relevant laboratory examinations were determined. Results: (1) The serum PCT level of general infection group was higher than those of local infection group, virus infection group and non-infection group (P0.01), and the serum PCT level of local infection group was higher than those of virus infection group and non-infection group (P0.01). (2) The serum CRP level of bacterial infection was higher than those of virus infection and non-infection groups (P0.001). There was no significant difference of CRP level between general infection group and local infection group (P0.05). (3) Discriminant: Y1=0.011CRP+0.158PCT+0.007day-1.972, Y2=0.031CRP+0.413PCT+0.005day-2.365. There was a value in clinical diagnosis. Conclusion: The serum PCT and CRP can be clinical indicators to diagnose general bacterial infections, PCT is superior to CRP in differentiating general infection, local infection and virus infection. The discriminant is helpful to diagnose general bacterial infections.