A randomized controlled trial of sparfloxacin intravenously. vs ofloxacin intravenously. in the treatment of the acute respiratory infections

Objective To evaluate the clinical efficacy and safety of sparfloxacin in treatment of the acute respiratory tract infections. Methods A randomized-controlled clinical trial was carried out .Sparfloxacin 200mg once daily and ofloxacin, as a contral drug, 200mg twice a day, both drugs were given by infusion for 7-14 days .There were 30 ca.ses in each group. Results The clinical cure rates and the clinical efficacy rates of the two groups were 33.33% , 26.67% ,and 80.00% , 76.67% respetively. The bacterial clearance rates were 89.66% and 89.29 % respectively. The adverse drug reaction rates were 13.33% and 16.67% respectively. There were no statistical differences between the two groups (P 0.05) . Photosensitive reaction was not observed in this study. Conclusion Sparfloxacin was effective in the treatment of the respiratory infections.