Relationship between the levels of serum cystatin C and high-sensitivity C- reactive protein and acute coronary syndrome in elderly patients

Objective To investigate the clinical significance and association between serum Cys C,hsCRP and acute coronary syndrome( ACS) in elderly patients. Methods A total of 172 elderly patients were selected by coronary angiography,including 46 patients with acute myocardial infarction( AMI),44 patients with unstable angina pectoris( UAP),42 patients with stable angina pectoris( SAP) and 40 healthy cases as controls. Levels of Cys C and hsCRP in serum were measured by immunoturbidimetry( ITM) in all cases. The general information and serum biochemical indexes of all the objects were also collected. Results( 1) There were no statistical differences in age,sex,smoking,hypertension,diabetes and hyperlipidemia among all groups( P 0. 05).( 2) Cys C levels were significantly higher in UAP patients than those in SAP patients and controls,while serum Cys C in AMI patients were much lower than those in SAP patients and controls( P 0. 05).( 3) Serum hsCRP concentrations in ACS groups were significantly higher than those in SAP group and control group,while hsCRP levels in ACS,AMI group were much higher than UAP group and the difference was statistically significant( P 0. 05). Conclusion Levels of Cys C and hsCRP in serum are closely related to ACS in elderly patients,which possibly may be risk factors for elderly ACS. Thus,combined measurement of serum Cys C and hsCRP levels may be valuable for the diagnosis and prognosis of elderly ACS.