2008•Biaoji mianyi fenxi yu linchuangRequires access

A Study of Sensitivity and Specificity of CD64 Expression in Acute Myeloid Leukemia

Yu Li

Abstract

To study the sensitivity and specificity of CD64 in immunotyping of acute myeloid leukemia(AML).The bone marrow cells from 132 patients with AML were labelled with a series of antigens and were analyzed by flow cytometry.CD64 has high sensitivity in patients with acute myelomonocytic leukemia(M4) 96.4% and acute monocytic leukemia(M5)(96.4% and 100%,respectively).The expressions of CD64 was very low on patients with other kinds of AML(M0,M1,M2,M3,M6,M7).The specificity of CD64 in patients with M4 and M5 was 56.5%.The results suggest that the CD64 is helpful in the differential diagnosis of M4 and M5 in AML patients.

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Key concepts: CD64, Medicine, Myeloid leukemia, Acute leukemia, Myeloid, Flow cytometry, Leukemia, Bone marrow