Study of Astragalus Injection on Prevention of Contrast Induced Nephrotoxity after Percutaneous Coronary Intervention

Objective To study the validity of astragalus injection on contrast induced nephrotoxity after percutaneous coronary intervention,and find out a new clinical method for prevention and treatment with it. Methods 52 patients were randomly divided into two groups:control group in which 26 cases were treated with 0.9% NaCl injection[1.0~1.5mL/(kg·h)] and treatment group in which 26 cases were treated with astragalus injection[40mL Astragalus injection were added into 250mL 5% glucose,1.0~1.5mL/(kg·h)]. Results There was a very significant difference between control group and treatment group in value-added(30.2±15.6 vs 63.7±22.4,P0.05= and its rate(10.8%±5.2% vs 26.9%±10.2%,P0.05= of serum creatinine,the desending value(10.3±4.2 vs 15.1±3.9) and its rate(9.8±3.9 vs 14.3±4.5) of creatinine clearance,the rate of CIN(11.5% vs 34.6%) in treatment group were significantly lower than those in control group,and also had a significant difference between them(P0.05=. Conclusion Astragalus injection has a good protection on CIN.