2007•China Medical HeraldRequires access

Affection of BDNF on recovery of cerebral ischemia damage

Guo-Ping Tian

Abstract

Objective:To investigate the induction of BDNF( brain - derived neurotrophic factor) expression at different times after transient focal cerebral ischemia at protein levels in order to clarify the role of BDNF in cerebral ischemia.Methods:A transient middle cerebral artery occlusion (MCAO) model was used.Cellular changes of BDNF expression were observed by immunohistochemitry.Results:BDNF was upregulated during the early period after transient MCAO in the rat. BDNF expressed in the neurons, glial cells and vascular endothelial, which depended on times.Conclusion:The increasing expression of BDNF possibly affect the recovery of blood supply in the border region, offering academic basis for the sake of treating ischemia cerebral vascular disease using BDNF.

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Key concepts: Medicine, Ischemia, Middle cerebral artery, Neurotrophic factors, Brain-derived neurotrophic factor, Internal medicine, Transient (computer programming), Downregulation and upregulation