Effect of Danzhijiangtang Capsules on Leptin in Rats with Type 2 Diabetes Mellitus

Objective To explore the effects of Danzhijiangtang capsules on leptin in rats with type-2 diabetes mellitus(T2DM).Methods Sixty-nine male Wistar rats were randomly divided into blank control group(group A),model control group(group B)and four treatment groups:low-dose Dazhijiangtang group(group C),high-dose group(group D),western medicine group(group E),Dazhijiangtang combined with western medicine group(group F).Group A were fed with ordinary diet,group B and all treatment groups with high-calorie diet.After 4 weeks,T2DM models were prepared by small-dose intraperitoneal injection of streptozotocin.Following preparation,group A and group B were fed with 0 9% sodium chloride solution,groups C and D with Dazhijiangtang capsules(540 mg/kg and 1 080 mg/kg,respectively),group E with rosiglitazone maleate,group F with Dazhijiangtang capsules in combination with rosiglitazone maleate.Pre-and post-treatment fasting blood glucose(FBG)and post-treatment levels of FINS,plasma leptin and insulin sensitivity index(ISI)were determined.Results After preparation,group B and all treatment groups were significantly different from group A in FBG level(P0.01);after treatment,there was significant difference in FBG level between group B and all treatment groups except group C(P0.05);group B and all treatment groups except group F differed significantly from group A in FINS and ISI levels(P0.05);significant difference was noted in FINS and ISI between group B and all treatment groups except group C(P0.05);groups B,C and D were significantly different from group A in plasma leptin level(P0.05);significant difference was seen in plasma leptin level between group A and all treatment groups except group F(P0.05).Conclusion Dazhijiangtang capsules can effectively improve insulin resistance in T2DM rats,the mechanism of which may be related to increase of plasma leptin level.