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2012•Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhiRequires access

Analysis of HBV genotypes and gene mutations

Zhi Yao

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Abstract

【Objective】 To investigate the relation between HBV genetypes and P gene mutation.【Methods】 Using gene sequencing technology,102 HBV infected serum samples were detected.HBV mutations were identified by DNA Star compared with standard sequence.Genetypes were analyzed by viral genetyping tool.【Results】 HBV genetyping showed that 12 HBV type B patients,89 HBV type C patients and 1 HBV type D.Rate accounted for 11.8%,87.3% and 1% respectively of all the participants.P gene mutation results showed that 84 specimens were mutated in 102 cases,including 50 cases of YIDD,59.5%,24 of YVDD,28.6%,9 of 181V,10.7%,1 of 202G,1.2%.【Conclusions】 The popular HBV genotypes in Tianjin are genotype B and genotype C,type C is the major genotype.HBV P mutations and genotypes have no significant difference in Tianjin.

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What this paper is about

【Objective】 To investigate the relation between HBV genetypes and P gene mutation.【Methods】 Using gene sequencing technology,102 HBV infected serum samples were detected.HBV mutations were identified by DNA Star compared with standard sequence.Genetypes were analyzed by viral genetyping tool.【Results】 HBV genetyping showed that 12 HBV type B patients,89 HBV type C patients and 1 HBV type D.Rate accounted for 11.8%,87.3% and 1% respectively of all the participants.P gene mutation results showed that 84 specimens were mutated in 102 cases,including 50 cases of YIDD,59.5%,24 of YVDD,28.6%,9 of 181V,10.7%,1 of 202G,1.2%.【Conclusions】 The popular HBV genotypes in Tianjin are genotype B and genotype C,type C is the major genotype.HBV P mutations and genotypes have no significant difference in Tianjin.

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Available abstract

【Objective】 To investigate the relation between HBV genetypes and P gene mutation.【Methods】 Using gene sequencing technology,102 HBV infected serum samples were detected.HBV mutations were identified by DNA Star compared with standard sequence.Genetypes were analyzed by viral genetyping tool.【Results】 HBV genetyping showed that 12 HBV type B patients,89 HBV type C patients and 1 HBV type D.Rate accounted for 11.8%,87.3% and 1% respectively of all the participants.P gene mutation results showed that 84 specimens were mutated in 102 cases,including 50 cases of YIDD,59.5%,24 of YVDD,28.6%,9 of 181V,10.7%,1 of 202G,1.2%.【Conclusions】 The popular HBV genotypes in Tianjin are genotype B and genotype C,type C is the major genotype.HBV P mutations and genotypes have no significant difference in Tianjin.

Key concepts: Genotype, Virology, Biology, Gene, Hepatitis B virus, Mutation, Gene mutation, Molecular biology

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