Effects of Fresh Rehmanniae Radix and its Processed Products on Blood of Fevered and Bleeding Rats

Objective: To compare the different effects of fresh Rehmannia Radix and its processed products on the blood of fevered and bleeding rats. Method: The rat blood heating and bleeding model were established by giving dose of 15 g ·kg- 1decoction of Ginger combined with 5% ethanol for 15 days. After modeling,eighty SD male rats were randomly divided into model compared group,Yunnan Baiyao group,the Fresh Rehmanniae Radix group,the juice of Rehmanniae Radix group,the powder of Rehmanniae Radix group, the granule and decoction pieces of Rehmanniae Radix group. Every group was given corresponding drugs for 15 days. The dose was 0. 66,9,9,2,9,2 g·kg- 1. The following indexes were observed like appetite,amount of drinking water,water content of waste hemorheological parameters and the degree of bleeding about tongue, stomach and lung. By detect its blood and plasma viscosity,prothrombin time( PT),thrombin time( TT), activated partial thromboplastin time( APTT) and fibrinogen( FIB) to compare the effects of fresh Rehmannia Root and its processed products on the blood system. Result: The model group significantly elevated rectal temperature and the amount of drinking water,decreased the appetite,lost of weight,significantly reduced the content of fecal water( P 0. 05,P 0. 01),increased high blood viscosity,middle blood viscosity,low blood viscosity and blood plasma viscosity( P 0. 05,P 0. 01),significantly prolonged PT,APTT,TT( P 0. 05, P 0. 01),significantly increased FIB( P 0. 01). After being given with corresponding drugs,the series of heated symptoms of rats were obviously relieved,blood viscosity,blood plasma viscosity,PT,TT,APTT and FIB gradually go to normal level. By observed the pathological tissue, unprocessed and processed fresh R. glutinosa can improve the injured lung and stomach of blood of fevered and bleeding rats. Conclusion: fresh R. glutinosa and processed R. glutinosa can relieve blooding heating symptoms and bleeding in rats,and improve the abnormal hemorheological parameters and blood coagulation system.