Risk factors of pulmonary fungal infections in elderly patients with chronic obstructive pulmonary disease

OBJECTIVE To study the risk factors of pulmonary fungal infections in elderly patients with chronic obstructive pulmonary disease and put forward corresponding countermeasures so as to reduce the infection rate.METHODS A total of 67cases of elderly patients with chronic obstructive pulmonary disease complicated with pulmonary fungal infections were selected as the observation group,while 61cases without pulmonary infections were set as the control group,then the clinical treatment and the basic data were statistically analyzed and compared between the two groups.RESULTS The antibiotic use time of the observation group(17.15±7.22)d was significantly longer than that of the control group(8.39±3.04)d,the blood albumin level of the observation group was(28.28±4.60)(g/L),significantly lower than(35.63±3.57)(g/L)of the control group,which was significantly higher in the patients with the use of glucocorticoids more than 2weeks,the patients complicated with diabetes,the patients with respiratory failure,or the patients who underwent the mechanical ventilation of the observation group than in those of the control group,the difference was statistically significant(P0.05).Although the cases with renal dysfunction were more in the observation group than in the control group,the difference was not statistically significant.Multivariate regression analysis showed that the long-term use of antibiotics or corticosteroids,complication of hypoalbuminemia,diabetes,respiratory failure,and use of mechanical ventilation were the high-risk independent factors of the pulmonary fungal infections(P0.05).Of totally 67 cases of patients complicated with pulmonary infections,there were 50(74.63%)cases with Candida infections,among which 29(43.28%)cases were with Candida albican infections,and 13(19.40%)cases with Candida tropicalis infections.CONCLUSION Although the incidence of pulmonary fungal infections in the patients with chronic obstructive pulmonary disease is related to the treatment,the prevention is even more importance.For the elderly patients with chronic obstructive pulmonary disease,it is necessary to reasonably use antibiotics or corticosteroids,reduce the invasive operation,actively treat the complications,and improve the immunity of the patients.