The diagnosis and treatment of the severe pulmonary infection in kidney transplantation patients

Purpose:To study the diagnosis and treatment of the severe pulmonary infection in kidney transplantation patients.Methods: The clinical data of 28 patients with the severe pulmonary infection following kidney transplantation were retrospectively analyzed.Results: ①microorganisms could be detected in 26 cases out of 28 kidney transplantation patients with the severe pulmonary infection.The main etiological causes according to their frequency and type were :Bacteria (26 cases ,Klebsiella friedlanderi,Mycobacterium tuberculosis,Pseudomonas,Aureus staphylococcus,Bacillus cloacae,etc.), Cytomegalovirus (8 cases) and Fungus (6 cases,Candida albians,Candida tropicals,Penicillum patulum). 46.1 %(12/26)of the patients suffered from one organism infection,and 53.9 % (14/26) suffered from mixed infection.② In 64.3 %(18/28)of patients the severe pulmonary infection happened within 6 months after renal transplantation.③Through positive rescue treatment ,23 cases ( 82.1 %) was cured and 5 died.Conclusions:Intensive care and active measures should be given to the severe pulmonary infection patients after kidney transplantation.The key to the successful treatment involved with the diagnosis of etiology in early stage,the selection of effective antibiontics according to the etiology, the adjustment of immunosuppressant, the correction of hypoproteinemia and hypoxia,and the use of respirator timely.